› 2li9

Solution NMR

Metal binding domain of rat beta-amyloid

Released:
DOI: 10.2210/pdb2li9/pdb
PDB entry 2li9 coloured by chain, ensemble of 20 models, front view.
PDB entry 2li9 coloured by chain, ensemble of 20 models, side view.
PDB entry 2li9 coloured by chain, ensemble of 20 models, top view.
Source organism: Rattus norvegicus
Primary publication:
NMR solution structure of rat aβ(1-16): toward understanding the mechanism of rats' resistance to Alzheimer's disease.
Istrate AN, Tsvetkov PO, Mantsyzov AB, Kulikova AA, Kozin SA, Makarov AA, Polshakov VI
Biophys J 102 136-43 (2012)
PMID: 22225807

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140210 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta protein 40 Chains: A, B
Molecule details ›
Chains: A, B
Length: 18 amino acids
Theoretical weight: 1.89 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: P08592 (Residues: 672-687; Coverage: 2%)
Gene names: A4, AD1, App

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 32%
Refinement method: simulated annealing, QM/MM geometry optimization
Expression system: Not provided

Quick links

Citations

4 review citations

Disruption of zinc homeostasis and the pathogenesis of senile dementia.
Kawahara et al. (2014)
3 more

5 mentions without citation

Amyloid beta: structure, biology and structure-based therapeutic development.
Chen et al. (2017)
4 more