› 2ll2

Solution NMR

Structure of the Cx43 C-terminal domain bound to tubulin

Released:
DOI: 10.2210/pdb2ll2/pdb
PDB entry 2ll2 coloured by chain, ensemble of 10 models, front view.
PDB entry 2ll2 coloured by chain, ensemble of 10 models, side view.
PDB entry 2ll2 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Phosphorylation controls the interaction of the connexin43 C-terminal domain with tubulin and microtubules.
Saidi Brikci-Nigassa A, Clement MJ, Ha-Duong T, Adjadj E, Ziani L, Pastre D, Curmi PA, Savarin P
Biochemistry 51 4331-42 (2012)
PMID: 22558917

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-538591 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gap junction alpha-1 protein Chain: A
Molecule details ›
Chain: A
Length: 26 amino acids
Theoretical weight: 2.72 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P17302 (Residues: 234-259; Coverage: 7%)
Gene names: GJA1, GJAL

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 53%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

17 review citations

Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.
Leybaert et al. (2017)
16 more

4 mentions without citation

Amyloid-β regulates gap junction protein connexin 43 trafficking in cultured primary astrocytes.
Maulik et al. (2020)
3 more