› 2ll4

Solution NMR

HADDOCK structure of TgMIC4-A5/lacto-N-biose complex, based on NOE-derived distance restraints

Released:
DOI: 10.2210/pdb2ll4/pdb
PDB entry 2ll4 coloured by chain, ensemble of 10 models, front view.
PDB entry 2ll4 coloured by chain, ensemble of 10 models, side view.
PDB entry 2ll4 coloured by chain, ensemble of 10 models, top view.
Source organism: Toxoplasma gondii
Primary publication:
Galactose recognition by the apicomplexan parasite Toxoplasma gondii.
Marchant J, Cowper B, Liu Y, Lai L, Pinzan C, Marq JB, Friedrich N, Sawmynaden K, Liew L, Chai W, Childs RA, Saouros S, Simpson P, Roque Barreira MC, Feizi T, Soldati-Favre D, Matthews S
J Biol Chem 287 16720-33 (2012)
PMID: 22399295

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195060 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Micronemal protein 4 Chain: M
Molecule details ›
Chain: M
Length: 82 amino acids
Theoretical weight: 9.16 KDa
Source organism: Toxoplasma gondii
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9XZH7 (Residues: 410-491; Coverage: 15%)
Gene names: MIC4, TgIb.0680
Sequence domains: PAN domain
Structure domains: Hepatocyte Growth Factor

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, GAL
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 90%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Screening for small molecule inhibitors of Toxoplasma gondii.
Kortagere S. (2012)
3 more

1 mention without citation

Galactose recognition by the apicomplexan parasite Toxoplasma gondii.
Marchant et al. (2012)