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NMR structure of FOXO3a transactivation domains (CR2C-CR3) in complex with CBP KIX domain (2l3b conformation)

Source organisms:
Biochemical function: histone acetyltransferase activity
Biological process: regulation of DNA-templated transcription
Cellular component: not assigned

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EC 2.3.1.48: Histone acetyltransferase

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Systematic name:
Acetyl-CoA:[protein]-L-lysine acetyltransferase
Alternative Name(s):
  • Acetyl-CoA:histone acetyltransferase
  • Histone acetokinase
  • Histone acetylase
  • Histone transacetylase
  • Lysine acetyltransferase
  • Nucleosome-histone acetyltransferase
  • Protein lysine acetyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF02172
Domain description: KIX domain
Occurring in:
  1. Histone lysine acetyltransferase CREBBP
The deposited structure of PDB entry 2lqi contains 1 copy of Pfam domain PF02172 (KIX domain) in Histone lysine acetyltransferase CREBBP. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036529
Domain description: Coactivator CBP, KIX domain superfamily
Occurring in:
  1. Histone lysine acetyltransferase CREBBP
IPR003101
Domain description: Coactivator CBP, KIX domain
Occurring in:
  1. Histone lysine acetyltransferase CREBBP
IPR032067
Domain description: FOXO protein, transactivation domain
Occurring in:
  1. Forkhead box protein O3
IPR032068
Domain description: FOXO protein, KIX-binding domain
Occurring in:
  1. Forkhead box protein O3
IPR013178
Domain description: Histone acetyltransferase Rtt109/CBP
Occurring in:
  1. Histone lysine acetyltransferase CREBBP

Structure domains

CATH CATH domains
6.10.250.1690
Class: Special
Architecture: Helix non-globular
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. Forkhead box protein O3
The deposited structure of PDB entry 2lqi contains 1 copy of CATH domain 6.10.250.1690 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Forkhead box protein O3. Showing 1 copy in chain B.
1.10.246.20
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Serum Albumin; Chain A, Domain 1
Homology: Coactivator CBP, KIX domain
Occurring in:
  1. Histone lysine acetyltransferase CREBBP
The deposited structure of PDB entry 2lqi contains 1 copy of CATH domain 1.10.246.20 (Serum Albumin; Chain A, Domain 1) in Histone lysine acetyltransferase CREBBP. Showing 1 copy in chain A.

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