› 2lsz

Solution NMR

NMR structure of duplex DNA containing the alpha-OH-PdG dA base pair: A mutagenic intermediate of acrolein

Released:
DOI: 10.2210/pdb2lsz/pdb
PDB entry 2lsz coloured by chain, ensemble of 26 models, front view.
PDB entry 2lsz coloured by chain, ensemble of 26 models, side view.
PDB entry 2lsz coloured by chain, ensemble of 26 models, top view.
Source organism: Synthetic construct
Primary publication:
NMR structure of duplex DNA containing the alpha-OH-PdG.dA base pair: a mutagenic intermediate of acrolein.
Zaliznyak T, Lukin M, El-khateeb M, Bonala R, Johnson F, de los Santos C
Biopolymers 93 391-401 (2010)
PMID: 20049919

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115562 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
DNA (5'-D(*CP*GP*TP*AP*CP*(63H)P*CP*AP*TP*GP*C)-3') Chain: B
Molecule details ›
Chain: B
Length: 11 nucleotides
Theoretical weight: 3.39 KDa
Source organism: Synthetic construct
Expression system: Not provided
DNA (5'-D(*GP*CP*AP*TP*GP*AP*GP*TP*AP*CP*G)-3') Chain: D
Molecule details ›
Chain: D
Length: 11 nucleotides
Theoretical weight: 3.4 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand 63H 1 x 63H

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 32%
Refinement method: molecular dynamics
Expression system: Not provided

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Citations

1 review citation

DNA damage induced by endogenous aldehydes: current state of knowledge.
Voulgaridou et al. (2011)
2 other articles