› 2lz5

Solution NMR

Solution structure of a Novel Alpha-Conotoxin TxIB

Released:
DOI: 10.2210/pdb2lz5/pdb
PDB entry 2lz5 coloured by chain, ensemble of 20 models, front view.
PDB entry 2lz5 coloured by chain, ensemble of 20 models, side view.
PDB entry 2lz5 coloured by chain, ensemble of 20 models, top view.
Source organism: Conus textile
Primary publication:
Characterization of a novel α-conotoxin from conus textile that selectively targets α6/α3β2β3 nicotinic acetylcholine receptors.
Luo S, Zhangsun D, Wu Y, Zhu X, Hu Y, McIntyre M, Christensen S, Akcan M, Craik DJ, McIntosh JM
J Biol Chem 288 894-902 (2013)
PMID: 23184959

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125562 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-conotoxin TxIB Chain: A
Molecule details ›
Chain: A
Length: 17 amino acids
Theoretical weight: 1.75 KDa
Source organism: Conus textile
Expression system: Not provided
UniProt:
  • Canonical: K4RNX9 (Residues: 22-37; Coverage: 39%)
Sequence domains: Alpha conotoxin precursor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 50%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

12 review citations

Conotoxins targeting nicotinic acetylcholine receptors: an overview.
Lebbe et al. (2014)
11 more

5 mentions without citation

Venom-Derived Neurotoxins Targeting Nicotinic Acetylcholine Receptors.
Bekbossynova et al. (2021)
4 more