› 2lzw

Solution NMR

DNA duplex containing mispair-aligned O6G-heptylene-O6G interstrand cross-link

Released:
DOI: 10.2210/pdb2lzw/pdb
PDB entry 2lzw coloured by chain, ensemble of 11 models, front view.
PDB entry 2lzw coloured by chain, ensemble of 11 models, side view.
PDB entry 2lzw coloured by chain, ensemble of 11 models, top view.
Source organism: synthetic construct
Primary publication:
Structural basis of interstrand cross-link repair by O6-alkylguanine DNA alkyltransferase.
Denisov AY, McManus FP, O'Flaherty DK, Noronha AM, Wilds CJ
Org Biomol Chem 15 8361-8370 (2017)
PMID: 28937154

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115577 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*AP*AP*AP*GP*TP*TP*TP*CP*G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 11 nucleotides
Theoretical weight: 3.37 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand HP6 1 x HP6
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 16%
Refinement method: simulated annealing
Expression system: Not provided

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Citations

1 review citation

DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy.
Huang et al. (2021)