› 2m1g

Solution NMR

Parallel human telomeric quadruplex containing 2'F-ANA substitutions

Released:
DOI: 10.2210/pdb2m1g/pdb
PDB entry 2m1g coloured by chain, ensemble of 10 models, front view.
PDB entry 2m1g coloured by chain, ensemble of 10 models, side view.
PDB entry 2m1g coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Dramatic effect of furanose C2' substitution on structure and stability: directing the folding of the human telomeric quadruplex with a single fluorine atom.
Martín-Pintado N, Yahyaee-Anzahaee M, Deleavey GF, Portella G, Orozco M, Damha MJ, González C
J Am Chem Soc 135 5344-7 (2013)
PMID: 23521511

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115579 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*(GFL)P*GP*GP*T)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 3.79 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand GFL 2 x GFL

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 21%
Refinement method: molecular dynamics, simulated annealing
Expression system: Not provided

Quick links

Citations

2 review citations

Synthesis and biological applications of fluoro-modified nucleic acids.
Guo et al. (2017)
1 more