› 2m2d

Solution NMR

Human programmed cell death 1 receptor

Released:
DOI: 10.2210/pdb2m2d/pdb
PDB entry 2m2d coloured by chain, ensemble of 35 models, front view.
PDB entry 2m2d coloured by chain, ensemble of 35 models, side view.
PDB entry 2m2d coloured by chain, ensemble of 35 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure and interactions of the human programmed cell death 1 receptor.
Cheng X, Veverka V, Radhakrishnan A, Waters LC, Muskett FW, Morgan SH, Huo J, Yu C, Evans EJ, Leslie AJ, Griffiths M, Stubberfield C, Griffin R, Henry AJ, Jansson A, Ladbury JE, Ikemizu S, Carr MD, Davis SJ
OpenAccess logo J Biol Chem 288 11771-85 (2013)
PMID: 23417675

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172197 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Programmed cell death protein 1 Chain: A
Molecule details ›
Chain: A
Length: 118 amino acids
Theoretical weight: 13.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15116 (Residues: 34-150; Coverage: 44%)
Gene names: PD1, PDCD1
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 86%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Escherichia coli

Quick links

Citations

42 review citations

Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway.
Ohaegbulam et al. (2015)
41 more

10 mentions without citation

Structure and interactions of the human programmed cell death 1 receptor.
Cheng et al. (2013)
9 more