› 2m36

Solution NMR

Solution structure of the insecticidal spider-venom peptide Aps III

Released:
DOI: 10.2210/pdb2m36/pdb
PDB entry 2m36 coloured by chain, ensemble of 20 models, front view.
PDB entry 2m36 coloured by chain, ensemble of 20 models, side view.
PDB entry 2m36 coloured by chain, ensemble of 20 models, top view.
Source organism: Apomastus schlingeri
Primary publication:
The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels.
Bende NS, Kang E, Herzig V, Bosmans F, Nicholson GM, Mobli M, King GF
Biochem Pharmacol 85 1542-54 (2013)
PMID: 23473802

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155906 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mu-cyrtautoxin-As1a Chain: A
Molecule details ›
Chain: A
Length: 38 amino acids
Theoretical weight: 3.86 KDa
Source organism: Apomastus schlingeri
Expression system: Escherichia coli
UniProt:
  • Canonical: P49268 (Residues: 1-37; Coverage: 100%)
Sequence domains: Spider insecticidal peptide

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 95%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Diversity of peptide toxins from stinging ant venoms.
Aili et al. (2014)
2 more

2 mentions without citation

The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels.
Bende et al. (2013)
1 more