2m5y Citations

Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis.

Proc Natl Acad Sci U S A 110 E4790-7 (2013)
Cited: 58 times
EuropePMC logo PMID: 24248369

Abstract

Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator."

Reviews - 2m5y mentioned but not cited (1)

Articles - 2m5y mentioned but not cited (1)

  1. Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. Rath P, Huang C, Wang T, Wang T, Li H, Prados-Rosales R, Elemento O, Casadevall A, Nathan CF. Proc Natl Acad Sci U S A 110 E4790-7 (2013)


Reviews citing this publication (26)

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Articles citing this publication (30)

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  16. Toll-like Receptor 2 Prevents Neutrophil-Driven Immunopathology during Infection with Mycobacterium tuberculosis by Curtailing CXCL5 Production. Gopalakrishnan A, Dietzold J, Verma S, Bhagavathula M, Salgame P. Infect Immun 87 e00760-18 (2019)
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  23. Identification of Secreted O-Mannosylated Proteins From BCG and Characterization of Immunodominant Antigens BCG_0470 and BCG_0980. Deng G, Zhang W, Ji N, Zhai Y, Shi X, Liu X, Yang S. Front Microbiol 11 407 (2020)
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  26. Environmental and Taxonomic Drivers of Bacterial Extracellular Vesicle Production in Marine Ecosystems. Biller SJ, Coe A, Arellano AA, Dooley K, Silvestri SM, Gong JS, Yeager EA, Becker JW, Chisholm SW. Appl Environ Microbiol 89 e0059423 (2023)
  27. Immunogenicity of Mycobacterial Extracellular Vesicles Isolated From Host-Related Conditions Informs About Tuberculosis Disease Status. Schirmer S, Rauh L, Alebouyeh S, Delgado-Velandia M, Salgueiro VC, Lerma L, Serrano-Mestre JL, Azkargorta M, Elortza F, Lavín JL, García MJ, Tórtola Fernández MT, Gola S, Prados-Rosales R. Front Microbiol 13 907296 (2022)
  28. Generation of Monoclonal Antibodies against Ag85A Antigen of Mycobacterium tuberculosis and Application in a Competitive ELISA for Serodiagnosis of Bovine Tuberculosis. Xu Z, Hu T, Xia A, Li X, Liu Z, Min J, He J, Meng C, Yin Y, Chen X, Jiao X. Front Vet Sci 4 107 (2017)
  29. NOS2/miR-493-5p Signaling Regulates in the LPS-Induced Inflammatory Response in the RAW264.7 Cells. Li X, Yang Y, Lu N, Luo F, Fan R, Peng N. Biochem Genet 61 1097-1112 (2023)
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