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Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis.

Rath P, Huang C, Wang T, Wang T, Li H, Prados-Rosales R, Elemento O, Casadevall A, Nathan CF
Proc Natl Acad Sci U S A 110 E4790-7 (2013)
Cited: 58 times
EuropePMC logo PMID: 24248369

Abstract

Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator."

Reviews - 2m5y mentioned but not cited (1)

  1. Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery. Kim DH, Kang SM, Lee BJ. Molecules 22 E1447 (2017)

Articles - 2m5y mentioned but not cited (1)

  1. Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. Rath P, Huang C, Wang T, Wang T, Li H, Prados-Rosales R, Elemento O, Casadevall A, Nathan CF. Proc Natl Acad Sci U S A 110 E4790-7 (2013)


Reviews citing this publication (26)

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Articles citing this publication (30)

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