› 2mav

Solution NMR

NMR Structure of N2-IQ-dG at the G3 position in the NarI recognition sequence

Released:
DOI: 10.2210/pdb2mav/pdb
PDB entry 2mav coloured by chain, ensemble of 10 models, front view.
PDB entry 2mav coloured by chain, ensemble of 10 models, side view.
PDB entry 2mav coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Base-displaced intercalation of the 2-amino-3-methylimidazo[4,5-f]quinolone N2-dG adduct in the NarI DNA recognition sequence.
Stavros KM, Hawkins EK, Rizzo CJ, Stone MP
OpenAccess logo Nucleic Acids Res 42 3450-63 (2014)
PMID: 24366876

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115601 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
DNA_(5'-D(*CP*TP*CP*GP*GP*CP*GP*CP*CP*AP*TP*C)-3') Chain: A
Molecule details ›
Chain: A
Length: 12 nucleotides
Theoretical weight: 3.8 KDa
Source organism: Synthetic construct
Expression system: Not provided
DNA_(5'-D(*GP*AP*TP*GP*GP*CP*GP*CP*CP*GP*AP*G)-3') Chain: B
Molecule details ›
Chain: B
Length: 12 nucleotides
Theoretical weight: 3.73 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 41%
Refinement method: simulated annealing, molecular dynamics
Expression system: Not provided

Quick links

Citations

2 review citations

Repair-Resistant DNA Lesions.
Geacintov et al. (2017)
1 more

1 mention without citation

Base-displaced intercalation of the 2-amino-3-methylimidazo[4,5-f]quinolone N2-dG adduct in the NarI DNA recognition sequence.
Stavros et al. (2014)