› 2mfa

Solution NMR

Mambalgin-2

Released:
DOI: 10.2210/pdb2mfa/pdb
PDB entry 2mfa coloured by chain, ensemble of 20 models, front view.
PDB entry 2mfa coloured by chain, ensemble of 20 models, side view.
PDB entry 2mfa coloured by chain, ensemble of 20 models, top view.
Source organism: Dendroaspis polylepis polylepis
Primary publication:
Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2.
Schroeder CI, Rash LD, Vila-Farrés X, Rosengren KJ, Mobli M, King GF, Alewood PF, Craik DJ, Durek T
Angew Chem Int Ed Engl 53 1017-20 (2014)
PMID: 24323786

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143617 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mambalgin-2 Chain: A
Molecule details ›
Chain: A
Length: 57 amino acids
Theoretical weight: 6.56 KDa
Source organism: Dendroaspis polylepis polylepis
Expression system: Not provided
UniProt:
  • Canonical: P0DKS3 (Residues: 1-57; Coverage: 100%)
Sequence domains: Snake toxin cobra-type
Structure domains: CD59

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 76%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

16 review citations

International Union of Basic and Clinical Pharmacology. XCI. structure, function, and pharmacology of acid-sensing ion channels and the epithelial Na+ channel.
Kellenberger et al. (2015)
15 more

6 mentions without citation

Computational Studies of Snake Venom Toxins.
Ojeda et al. (2017)
5 more