› 2mfy

Solution NMR

Non-reducible analogues of alpha-conotoxin Vc1.1: [2,8]-trans dicarba Vc1.1

Released:
DOI: 10.2210/pdb2mfy/pdb
PDB entry 2mfy coloured by chain, ensemble of 20 models, front view.
PDB entry 2mfy coloured by chain, ensemble of 20 models, side view.
PDB entry 2mfy coloured by chain, ensemble of 20 models, top view.
Source organism: Conus victoriae
Primary publication:
Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors.
van Lierop BJ, Robinson SD, Kompella SN, Belgi A, McArthur JR, Hung A, MacRaild CA, Adams DJ, Norton RS, Robinson AJ
ACS Chem Biol 8 1815-21 (2013)
PMID: 23768016

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-550179 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-conotoxin Vc1a Chain: A
Molecule details ›
Chain: A
Length: 17 amino acids
Theoretical weight: 1.78 KDa
Source organism: Conus victoriae
Expression system: Not provided
UniProt:
  • Canonical: P69747 (Residues: 50-65; Coverage: 39%)
Sequence domains: Alpha conotoxin precursor

Ligands and Environments

No bound ligands
1 modified residue:
Ligand ABA 2 x ABA

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 37%
Refinement method: simulated annealing, torsion angle dynamics
Expression system: Not provided

Quick links

Citations

15 review citations

Conotoxin Interactions with α9α10-nAChRs: Is the α9α10-Nicotinic Acetylcholine Receptor an Important Therapeutic Target for Pain Management?
Mohammadi et al. (2015)
14 more