› 2mgn

Solution NMR

Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3

Released:
DOI: 10.2210/pdb2mgn/pdb
PDB entry 2mgn coloured by chain, ensemble of 10 models, front view.
PDB entry 2mgn coloured by chain, ensemble of 10 models, side view.
PDB entry 2mgn coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC(3).
Chung WJ, Heddi B, Hamon F, Teulade-Fichou MP, Phan AT
Angew Chem Int Ed Engl 53 999-1002 (2014)
PMID: 24356977

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115616 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*GP*AP*AP*GP*G)-3' Chain: A
Molecule details ›
Chain: A
Length: 24 nucleotides
Theoretical weight: 7.69 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand PQ3 1 x PQ3
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 32%
Refinement method: DGSA-distance geometry simulated annealing, simulated annealing, molecular dynamics
Expression system: Not provided

Quick links

Citations

10 review citations

G-quadruplex interacting small molecules and drugs: from bench toward bedside.
Müller et al. (2014)
9 more

18 mentions without citation

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy.
Ruggiero et al. (2018)
17 more