› 2mhh

Solution NMR

Solution structure of a EF-hand domain from sea urchin polycystin-2

Released:
DOI: 10.2210/pdb2mhh/pdb
PDB entry 2mhh coloured by chain, ensemble of 20 models, front view.
PDB entry 2mhh coloured by chain, ensemble of 20 models, side view.
PDB entry 2mhh coloured by chain, ensemble of 20 models, top view.
Source organism: Strongylocentrotus purpuratus
Primary publication:
The number and location of EF hand motifs dictates the calcium dependence of polycystin-2 function.
Kuo IY, Keeler C, Corbin R, Ćelić A, Petri ET, Hodsdon ME, Ehrlich BE
FASEB J 28 2332-46 (2014)
PMID: 24558196

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182237 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
EF-hand domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 96 amino acids
Theoretical weight: 10.74 KDa
Source organism: Strongylocentrotus purpuratus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7Z2B5 (Residues: 655-738; Coverage: 9%)
Gene name: PKD2
Structure domains: EF-hand

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 87%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Polycystin 2: A calcium channel, channel partner, and regulator of calcium homeostasis in ADPKD.
Brill et al. (2020)
3 more

2 mentions without citation

The number and location of EF hand motifs dictates the calcium dependence of polycystin-2 function.
Kuo et al. (2014)
1 more