› 2mkf

Solution NMR

Solution structure of the E81 deletion mutant of the tandem UIMs of RAP80

Released:
DOI: 10.2210/pdb2mkf/pdb
PDB entry 2mkf coloured by chain, ensemble of 20 models, front view.
PDB entry 2mkf coloured by chain, ensemble of 20 models, side view.
PDB entry 2mkf coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for impaired DNA damage response function associated with the RAP80 ΔE81 defect.
Anamika A, Markin CJ, Rout MK, Spyracopoulos L
J Biol Chem 289 12852-62 (2014)
PMID: 24627472

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188729 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
BRCA1-A complex subunit RAP80 Chain: A
Molecule details ›
Chain: A
Length: 62 amino acids
Theoretical weight: 6.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96RL1 (Residues: 74-131; Coverage: 8%)
Gene names: RAP80, RXRIP110, UIMC1
Sequence domains: RAP80 N-terminal ubiquitin interaction motif

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Chemical shift assignment: 36%
Expression system: Escherichia coli

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Citations

3 review citations

Molecular Basis for K63-Linked Ubiquitination Processes in Double-Strand DNA Break Repair: A Focus on Kinetics and Dynamics.
Lee et al. (2017)
2 more

3 mentions without citation

Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2.
Wang et al. (2020)
2 more