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Solution NMR

The solution structure of the MANEC-type domain from Hepatocyte Growth Factor Inhibitor 1 reveals an unexpected PAN/apple domain-type fold

Released:
DOI: 10.2210/pdb2msx/pdb
PDB entry 2msx coloured by chain, ensemble of 20 models, front view.
PDB entry 2msx coloured by chain, ensemble of 20 models, side view.
PDB entry 2msx coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The solution structure of the MANEC-type domain from hepatocyte growth factor activator inhibitor-1 reveals an unexpected PAN/apple domain-type fold.
Hong Z, Nowakowski M, Spronk C, Petersen SV, Andreasen PA, Koźmiński W, Mulder FA, Jensen JK
Biochem J 466 299-309 (2015)
PMID: 25510835

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128879 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kunitz-type protease inhibitor 1 Chain: A
Molecule details ›
Chain: A
Length: 114 amino acids
Theoretical weight: 12.84 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: O43278 (Residues: 47-152; Coverage: 22%)
Gene names: HAI1, SPINT1, UNQ223/PRO256
Sequence domains: MANEC domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 86%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Komagataella pastoris

Quick links

Citations

1 review citation

Applications of high dimensionality experiments to biomolecular NMR.
Nowakowski et al. (2015)
8 other articles

3 mentions without citation

To Tie or Not to Tie? That Is the Question.
Dabrowski-Tumanski et al. (2017)
2 more