› 2mud

Solution NMR

Structural modifications to a high-activity binding peptide located whitin the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys

Released:
DOI: 10.2210/pdb2mud/pdb
PDB entry 2mud coloured by chain, ensemble of 29 models, front view.
PDB entry 2mud coloured by chain, ensemble of 29 models, side view.
PDB entry 2mud coloured by chain, ensemble of 29 models, top view.
Source organism: Plasmodium falciparum
Primary publication:
Structural modifications to a high-activity binding peptide located within the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys.
Curtidor H, Torres MH, Alba MP, Patarroyo ME
Biol Chem 388 25-36 (2007)
PMID: 17214546

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173236 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Variant-specific surface protein Chain: A
Molecule details ›
Chain: A
Length: 22 amino acids
Theoretical weight: 2.43 KDa
Source organism: Plasmodium falciparum
Expression system: Not provided
UniProt:
  • Canonical: Q26031 (Residues: 21-40; Coverage: 1%)
Gene name: var-1
Sequence domains: N-terminal segments of PfEMP1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 38%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Not provided

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Citations

1 review citation

Molecular approaches to field studies of malaria.
Beck et al. (2008)
6 other articles