› 2mus

Solution NMR

HADDOCK calculated model of LIN5001 bound to the HET-s amyloid

Released:
DOI: 10.2210/pdb2mus/pdb
PDB entry 2mus coloured by chain, ensemble of 4 models, front view.
PDB entry 2mus coloured by chain, ensemble of 4 models, side view.
PDB entry 2mus coloured by chain, ensemble of 4 models, top view.
Source organism: Podospora anserina
Primary publication:
Structure-based drug design identifies polythiophenes as antiprion compounds.
Herrmann US, Schütz AK, Shirani H, Huang D, Saban D, Nuvolone M, Li B, Ballmer B, Åslund AK, Mason JJ, Rushing E, Budka H, Nyström S, Hammarström P, Böckmann A, Caflisch A, Meier BH, Nilsson KP, Hornemann S, Aguzzi A
Sci Transl Med 7 299ra123 (2015)
PMID: 26246168

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169928 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heterokaryon incompatibility protein s Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 79 amino acids
Theoretical weight: 8.67 KDa
Source organism: Podospora anserina
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q03689 (Residues: 217-289; Coverage: 25%)
Gene names: het-s, small s
Sequence domains: Het-s 218-289

Ligands and Environments

1 bound ligand:
Ligand 3LS 1 x 3LS
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Chemical shift assignment: 7%
Refinement method: molecular dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

19 review citations

Prions, prionoids and protein misfolding disorders.
Scheckel et al. (2018)
18 more

3 mentions without citation

Amyloid fibril polymorphism: a challenge for molecular imaging and therapy.
Fändrich et al. (2018)
2 more