› 2mxq

Solution NMR

The solution structure of DEFA1, a highly potent antimicrobial peptide from the horse

Released:
DOI: 10.2210/pdb2mxq/pdb
PDB entry 2mxq coloured by chain, ensemble of 10 models, front view.
PDB entry 2mxq coloured by chain, ensemble of 10 models, side view.
PDB entry 2mxq coloured by chain, ensemble of 10 models, top view.
Source organism: Equus caballus
Primary publication:
Solution structure and functional studies of the highly potent equine antimicrobial peptide DEFA1.
Michalek M, Jung S, Shomali MR, Cauchard S, Sönnichsen FD, Grötzinger J
Biochem Biophys Res Commun 459 668-72 (2015)
PMID: 25769951

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108160 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-defensin 1 Chain: A
Molecule details ›
Chain: A
Length: 34 amino acids
Theoretical weight: 4.09 KDa
Source organism: Equus caballus
Expression system: Not provided
UniProt:
  • Canonical: A6YB85 (Residues: 65-98; Coverage: 43%)
Gene name: DEFA1
Sequence domains: Mammalian defensin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 32%
Refinement method: torsion angle dynamics
Expression system: Not provided

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Citations

1 review citation

Paneth cells in farm animals: current status and future direction.
Cui et al. (2023)

2 mentions without citation

In Silico Structural Evaluation of Short Cationic Antimicrobial Peptides.
Passarini et al. (2018)
1 more