› 2n02

Solution NMR

Solution structure of the A147T variant of the mitochondrial translocator protein (tspo) in complex with pk11195

Released:
DOI: 10.2210/pdb2n02/pdb
PDB entry 2n02 coloured by chain, ensemble of 20 models, front view.
PDB entry 2n02 coloured by chain, ensemble of 20 models, side view.
PDB entry 2n02 coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Structural Integrity of the A147T Polymorph of Mammalian TSPO.
Jaremko M, Jaremko Ł, Giller K, Becker S, Zweckstetter M
Chembiochem 16 1483-9 (2015)
PMID: 25974690

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-546599 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Translocator protein Chain: A
Molecule details ›
Chain: A
Length: 169 amino acids
Theoretical weight: 18.83 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P50637 (Residues: 1-169; Coverage: 100%)
Gene names: Bzrp, Mbr, Tspo
Sequence domains: TspO/MBR family
Structure domains: TspO/MBR protein

Ligands and Environments

1 bound ligand:
Ligand PKA 1 x PKA
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 84%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Recent Developments in TSPO PET Imaging as A Biomarker of Neuroinflammation in Neurodegenerative Disorders.
Werry et al. (2019)
9 more

6 mentions without citation

VDAC1 and the TSPO: Expression, Interactions, and Associated Functions in Health and Disease States.
Shoshan-Barmatz et al. (2019)
5 more