› 2n19

Solution NMR

STIL binding to the Polo-box domain 3 of PLK4 regulates centriole duplication

Released:
DOI: 10.2210/pdb2n19/pdb
PDB entry 2n19 coloured by chain, ensemble of 20 models, front view.
PDB entry 2n19 coloured by chain, ensemble of 20 models, side view.
PDB entry 2n19 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
STIL binding to Polo-box 3 of PLK4 regulates centriole duplication.
Arquint C, Gabryjonczyk AM, Imseng S, Böhm R, Sauer E, Hiller S, Nigg EA, Maier T
OpenAccess logo Elife 4 (2015)
PMID: 26188084

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-517266 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PLK4 Chain: A
Molecule details ›
Chain: A
Length: 88 amino acids
Theoretical weight: 9.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00444 (Residues: 884-970; Coverage: 9%)
Gene names: PLK4, SAK, STK18
Structure domains: POLO box domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 48%
Refinement method: torsion angle dynamics, molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

22 review citations

Centrosome function and assembly in animal cells.
Conduit et al. (2015)
21 more

2 mentions without citation

STIL binding to Polo-box 3 of PLK4 regulates centriole duplication.
Arquint et al. (2015)
1 more