› 2n74

Solution NMR

Solution Structure of the RNA-Binding domain of non-structural protein 1 from the 1918 H1N1 influenza virus

Released:
DOI: 10.2210/pdb2n74/pdb
PDB entry 2n74 coloured by chain, ensemble of 16 models, front view.
PDB entry 2n74 coloured by chain, ensemble of 16 models, side view.
PDB entry 2n74 coloured by chain, ensemble of 16 models, top view.
Source organism: Influenza A virus (A/Brevig Mission/1/1918(H1N1))
Primary publication:
Structural Basis for a Novel Interaction between the NS1 Protein Derived from the 1918 Influenza Virus and RIG-I.
Jureka AS, Kleinpeter AB, Cornilescu G, Cornilescu CC, Petit CM
Structure 23 2001-10 (2015)
PMID: 26365801

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189304 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Non-structural protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 73 amino acids
Theoretical weight: 8.41 KDa
Source organism: Influenza A virus (A/Brevig Mission/1/1918(H1N1))
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99AU3 (Residues: 1-73; Coverage: 32%)
Gene name: NS
Sequence domains: Influenza non-structural protein (NS1)
Structure domains: S15/NS1, RNA-binding

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 41%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

19 review citations

Protective Antibodies Against Influenza Proteins.
Padilla-Quirarte et al. (2019)
18 more

5 mentions without citation

The structural and functional diversity of metabolite-binding riboswitches.
Roth et al. (2009)
4 more