› 2nok

X-ray diffraction
3Å resolution

Crystal Structure of an RNA domain from Hepatitis C virus.

Released:
DOI: 10.2210/pdb2nok/pdb
PDB entry 2nok coloured by chain, front view.
PDB entry 2nok coloured by chain, side view.
PDB entry 2nok coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Functional architecture of HCV IRES domain II stabilized by divalent metal ions in the crystal and in solution.
Dibrov SM, Johnston-Cox H, Weng YH, Hermann T
Angew Chem Int Ed Engl 46 226-9 (2007)
PMID: 17131443

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196536 (preferred)
Entry contents:
2 distinct RNA molecules
Macromolecules (2 distinct):
5'-R(*CP*GP*GP*AP*GP*GP*AP*AP*CP*UP*AP*CP*UP*GP*UP*CP*UP*UP*CP*AP*CP*GP*CP*C)-3' Chains: A, C
Molecule details ›
Chains: A, C
Length: 24 nucleotides
Theoretical weight: 7.64 KDa
Source organism: Synthetic construct
Expression system: Not provided
5'-R(*GP*CP*GP*UP*GP*UP*CP*GP*UP*GP*CP*AP*GP*CP*CP*UP*CP*CP*GP*G)-3' Chains: B, D
Molecule details ›
Chains: B, D
Length: 20 nucleotides
Theoretical weight: 6.41 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand MG 8 x MG
Ligand MN 5 x MN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 62.098Å b: 65.351Å c: 92.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.259 0.257 0.302
Expression system: Not provided

Quick links

Citations

13 review citations

The Emerging Role of RNA as a Therapeutic Target for Small Molecules.
Connelly et al. (2016)
12 more

5 mentions without citation

Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site.
Dibrov et al. (2014)
4 more