2o4v Citations

An arginine ladder in OprP mediates phosphate-specific transfer across the outer membrane.

Nat Struct Mol Biol 14 85-7 (2007)
Cited: 42 times
EuropePMC logo PMID: 17187075

Abstract

The outer membrane protein OprP mediates the transport of essential phosphate anions into the pathogenic bacterium Pseudomonas aeruginosa. Here we report the crystallographic structure of trimeric OprP at 1.9-A resolution, revealing an unprecedented 9-residue arginine 'ladder' that spans from the extracellular surface down through a constriction zone where phosphate is coordinated. Lysine residues coat the inner periplasmic surface, creating an 'electropositive sink' that pulls the phosphates through the eyelet and into the cell.

Reviews - 2o4v mentioned but not cited (2)

  1. The structural biology of β-barrel membrane proteins: a summary of recent reports. Fairman JW, Noinaj N, Buchanan SK. Curr Opin Struct Biol 21 523-531 (2011)
  2. The bacterial outer membrane β-barrel assembly machinery. Kim KH, Aulakh S, Paetzel M. Protein Sci 21 751-768 (2012)

Articles - 2o4v mentioned but not cited (12)



Reviews citing this publication (6)

  1. Microbe-host interactions: structure and role of Gram-negative bacterial porins. Galdiero S, Falanga A, Cantisani M, Tarallo R, Della Pepa ME, D'Oriano V, Galdiero M. Curr Protein Pept Sci 13 843-854 (2012)
  2. Modeling and simulation of ion channels. Maffeo C, Bhattacharya S, Yoo J, Wells D, Aksimentiev A. Chem Rev 112 6250-6284 (2012)
  3. Porins in prokaryotes and eukaryotes: common themes and variations. Zeth K, Thein M. Biochem J 431 13-22 (2010)
  4. Protein oligomerization in the bacterial outer membrane (Review). Meng G, Fronzes R, Chandran V, Remaut H, Waksman G. Mol Membr Biol 26 136-145 (2009)
  5. Molecular Simulations of Gram-Negative Bacterial Membranes: A Vignette of Some Recent Successes. Parkin J, Chavent M, Khalid S. Biophys J 109 461-468 (2015)
  6. Forward or backward, that is the question: phospholipid trafficking by the Mla system. Abellon-Ruiz J. Emerg Top Life Sci 7 125-135 (2023)

Articles citing this publication (22)