› 2o7u

X-ray diffraction
2.8Å resolution

Crystal structure of K206E/K296E mutant of the N-terminal half molecule of human transferrin

Released:
DOI: 10.2210/pdb2o7u/pdb
PDB entry 2o7u coloured by chain, front view.
PDB entry 2o7u coloured by chain, side view.
PDB entry 2o7u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of two mutants that probe the role in iron release of the dilysine pair in the N-lobe of human transferrin.
Baker HM, Nurizzo D, Mason AB, Baker EN
Acta Crystallogr D Biol Crystallogr 63 408-14 (2007)
PMID: 17327678

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serotransferrin Chains: A, B, C, D, E, F, G, H, I
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I
Length: 337 amino acids
Theoretical weight: 37.22 KDa
Source organism: Homo sapiens
Expression system: Mesocricetus auratus
UniProt:
  • Canonical: P02787 (Residues: 20-356; Coverage: 50%)
Gene names: PRO1400, TF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand FE 9 x FE
Ligand CO3 9 x CO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: C2
Unit cell:
a: 169.462Å b: 97.897Å c: 208.953Å
α: 90° β: 90.01° γ: 90°
R-values:
R R work R free
0.231 0.23 0.259
Expression system: Mesocricetus auratus

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Citations

1 review citation

Computational approaches for deciphering the equilibrium and kinetic properties of iron transport proteins.
Abdizadeh et al. (2017)
3 other articles