EC 1.1.1.169: 2-dehydropantoate 2-reductase
Reaction catalysed:
(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH
Systematic name:
(R)-pantoate:NADP(+) 2-oxidoreductase
Alternative Name(s):
- 2-ketopantoate reductase
- 2-ketopantoic acid reductase
- 2-oxopantoate reductase
- KPA reductase
- Ketopantoate reductase
- Ketopantoic acid reductase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR008927
Domain description:
6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
Occurring in:
Occurring in:
Structure domains
CATH domains
1.10.1040.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Homology:
N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2ofp</span> contains 2 copies of CATH domain <span class='highlight'>1.10.1040.10 (N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2)</span> in <span class='highlight'>2-dehydropantoate 2-reductase</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 2ofp contains 2 copies of CATH domain 1.10.1040.10 (N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2) in 2-dehydropantoate 2-reductase. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/2ofp_1_B_CATH_1.10.1040.10_image-200x200.png)
SCOP annotations
69084
Class:
All alpha proteins
Fold:
6-phosphogluconate dehydrogenase C-terminal domain-like
Superfamily:
6-phosphogluconate dehydrogenase C-terminal domain-like
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2ofp</span> contains 2 copies of SCOP domain <span class='highlight'>69084 (Ketopantoate reductase PanE)</span> in <span class='highlight'>2-dehydropantoate 2-reductase</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 2ofp contains 2 copies of SCOP domain 69084 (Ketopantoate reductase PanE) in 2-dehydropantoate 2-reductase. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/2ofp_1_B_SCOP_69084_image-200x200.png)
51868
Class:
Alpha and beta proteins (a/b)
Fold:
NAD(P)-binding Rossmann-fold domains
Superfamily:
NAD(P)-binding Rossmann-fold domains
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2ofp</span> contains 2 copies of SCOP domain <span class='highlight'>51868 (6-phosphogluconate dehydrogenase-like, N-terminal domain)</span> in <span class='highlight'>2-dehydropantoate 2-reductase</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 2ofp contains 2 copies of SCOP domain 51868 (6-phosphogluconate dehydrogenase-like, N-terminal domain) in 2-dehydropantoate 2-reductase. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/2ofp_1_B_SCOP_51868_image-200x200.png)