2om0

X-ray diffraction
2.05Å resolution

Structure of human insulin in presence of urea at pH 6.5

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134235 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin A chain Chains: 1, 3, A, C, E, G, I, K, Q, S, U, X, a, c, e, g, i, k
Molecule details ›
Chains: 1, 3, A, C, E, G, I, K, Q, S, U, X, a, c, e, g, i, k
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
Insulin B chain Chains: 2, 4, B, D, F, H, J, L, R, T, V, Y, b, d, f, h, j, l
Molecule details ›
Chains: 2, 4, B, D, F, H, J, L, R, T, V, Y, b, d, f, h, j, l
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-2
Spacegroup: C2221
Unit cell:
a: 58.936Å b: 219.318Å c: 223.674Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.227