› 2or8

X-ray diffraction
2.5Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177763 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatitis A virus cellular receptor 1 homolog Chains: A, B
Molecule details ›
Chains: A, B
Length: 116 amino acids
Theoretical weight: 12.98 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q5QNS5 (Residues: 19-130; Coverage: 38%)
Gene names: Havcr1, Kim1, Tim1, Timd1
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 44.49Å b: 55.74Å c: 75.53Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.241 0.232 0.278
Expression system: Escherichia coli BL21

Quick links

Citations

32 review citations

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.
Anderson et al. (2016)
31 more

14 mentions without citation

TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity.
Freeman et al. (2010)
13 more