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Crystal structure of Acetylornithine aminotransferase (EC 2.6.1.11) (ACOAT) (TM1785) from Thermotoga maritima at 1.40 A resolution

Source organism: Thermotoga maritima MSB8
Biochemical function: identical protein binding
Biological process: arginine biosynthetic process
Cellular component: cytoplasm

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EC 2.6.1.11: Acetylornithine transaminase

Reaction catalysed:
N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate
Systematic name:
N(2)-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase
Alternative Name(s):
  • 2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase
  • ACOAT
  • Acetylornithine 5-aminotransferase
  • Acetylornithine aminotransferase
  • Acetylornithine delta-transaminase
  • N(2)-acetyl-L-ornithine:2-oxoglutarate aminotransferase
  • N(2)-acetylornithine 5-transaminase
  • N-acetylornithine aminotransferase
  • N-acetylornithine-delta-transaminase
  • Succinylornithine aminotransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00202
Domain description: Aminotransferase class-III
Occurring in:
  1. Acetylornithine aminotransferase
The deposited structure of PDB entry 2ord contains 2 copies of Pfam domain PF00202 (Aminotransferase class-III) in Acetylornithine aminotransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005814
Domain description: Aminotransferase class-III
Occurring in:
  1. Acetylornithine aminotransferase
IPR004636
Domain description: Acetylornithine/Succinylornithine transaminase family
Occurring in:
  1. Acetylornithine aminotransferase
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Acetylornithine aminotransferase
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. Acetylornithine aminotransferase
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Acetylornithine aminotransferase

Structure domains

CATH CATH domains
3.90.1150.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aspartate Aminotransferase, domain 1
Homology: Aspartate Aminotransferase, domain 1
Occurring in:
  1. Acetylornithine aminotransferase
The deposited structure of PDB entry 2ord contains 2 copies of CATH domain 3.90.1150.10 (Aspartate Aminotransferase, domain 1) in Acetylornithine aminotransferase. Showing 1 copy in chain A.
3.40.640.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aspartate Aminotransferase; domain 2
Homology: Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Occurring in:
  1. Acetylornithine aminotransferase
The deposited structure of PDB entry 2ord contains 2 copies of CATH domain 3.40.640.10 (Aspartate Aminotransferase; domain 2) in Acetylornithine aminotransferase. Showing 1 copy in chain A.

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