› 2p2h

X-ray diffraction
1.95Å resolution

Crystal structure of the VEGFR2 kinase domain in complex with a pyridinyl-triazine inhibitor

Released:
DOI: 10.2210/pdb2p2h/pdb
PDB entry 2p2h coloured by chain, front view.
PDB entry 2p2h coloured by chain, side view.
PDB entry 2p2h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.
Hodous BL, Geuns-Meyer SD, Hughes PE, Albrecht BK, Bellon S, Bready J, Caenepeel S, Cee VJ, Chaffee SC, Coxon A, Emery M, Fretland J, Gallant P, Gu Y, Hoffman D, Johnson RE, Kendall R, Kim JL, Long AM, Morrison M, Olivieri PR, Patel VF, Polverino A, Rose P, Tempest P, Wang L, Whittington DA, Zhao H
J Med Chem 50 611-26 (2007)
PMID: 17253678

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153084 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vascular endothelial growth factor receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 314 amino acids
Theoretical weight: 36.28 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P35968 (Residues: 815-1172; Coverage: 23%)
Gene names: FLK1, KDR, VEGFR2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 994 1 x 994
1 modified residue:
Ligand PTR 2 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21212
Unit cell:
a: 66.595Å b: 136.915Å c: 58.725Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.205 0.229
Expression system: Trichoplusia ni

Quick links

Citations

5 review citations

Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system.
Augustin et al. (2009)
4 more

13 mentions without citation

Predicting new indications for approved drugs using a proteochemometric method.
Dakshanamurthy et al. (2012)
12 more