2p34 › Citations

Structural analysis of Canavalia maritima and Canavalia gladiata lectins complexed with different dimannosides: new insights into the understanding of the structure-biological activity relationship in legume lectins.

Bezerra GA, Oliveira TM, Moreno FB, de Souza EP, da Rocha BA, Benevides RG, Delatorre P, de Azevedo WF, Cavada BS
J Struct Biol 160 168-76 (2007)
Related entries: 2ef6, 2ovu, 2ow4, 2p2k, 2p37

Cited: 27 times
EuropePMC logo PMID: 17881248

Abstract

Plant lectins, especially those purified from species of the Leguminosae family, represent the best studied group of carbohydrate-binding proteins. The legume lectins from Diocleinae subtribe are highly similar proteins that present significant differences in the potency/efficacy of their biological activities. The structural studies of the interactions between lectins and sugars may clarify the origin of the distinct biological activities observed in this high similar class of proteins. In this way, this work presents a crystallographic study of the ConM and CGL (agglutinins from Canavalia maritima and Canavalia gladiata, respectively) in the following complexes: ConM/CGL:Man(alpha1-2)Man(alpha1-O)Me, ConM/CGL:Man(alpha1-3)Man(alpha1-O)Me and ConM/CGL:Man(alpha1-4)Man(alpha1-O)Me, which crystallized in different conditions and space group from the native proteins. The structures were solved by molecular replacement, presenting satisfactory values for R(factor) and R(free). Comparisons between ConM, CGL and ConA (Canavalia ensiformis lectin) binding mode with the dimannosides in subject, presented different interactions patterns, which may account for a structural explanation of the distincts biological properties observed in the lectins of Diocleinae subtribe.

Articles - 2p34 mentioned but not cited (8)

  1. An integrated linkage, chromosome, and genome map for the yellow fever mosquito Aedes aegypti. Timoshevskiy VA, Severson DW, Debruyn BS, Black WC, Sharakhov IV, Sharakhova MV. PLoS Negl Trop Dis 7 e2052 (2013)
  2. Extracellular Vesicles Secreted by Corneal Epithelial Cells Promote Myofibroblast Differentiation. McKay TB, Hutcheon AEK, Zieske JD, Ciolino JB. Cells 9 E1080 (2020)
  3. In silico identification of potential targets and drugs for non-small cell lung cancer. Huang CH, Wu MY, Chang PM, Huang CY, Ng KL. IET Syst Biol 8 56-66 (2014)
  4. A bead-based cleavage method for large-scale identification of protease substrates. Wang C, Ye M, Wei X, Bian Y, Cheng K, Zou H. Sci Rep 6 22645 (2016)
  5. A comparative study on normal and obese mice indicates that the secretome of mesenchymal stromal cells is influenced by tissue environment and physiopathological conditions. Ayaz-Guner S, Alessio N, Acar MB, Aprile D, Özcan S, Di Bernardo G, Peluso G, Galderisi U. Cell Commun Signal 18 118 (2020)
  6. Proteomic analysis reveals dysregulated cell signaling in ejaculated spermatozoa from infertile men. Samanta L, Sharma R, Cui Z, Agarwal A. Asian J Androl 21 121-130 (2019)
  7. Insight Into the Metabolic Adaptations of Electrically Pulse-Stimulated Human Myotubes Using Global Analysis of the Transcriptome and Proteome. Mengeste AM, Nikolić N, Dalmao Fernandez A, Feng YZ, Nyman TA, Kersten S, Haugen F, Kase ET, Aas V, Rustan AC, Thoresen GH. Front Physiol 13 928195 (2022)
  8. Shared 6mer Peptides of Human and Omicron (21K and 21L) at SARS-CoV-2 Mutation Sites. Adiguzel Y, Shoenfeld Y. Antibodies (Basel) 11 68 (2022)


Reviews citing this publication (3)

  1. ConA-Like Lectins: High Similarity Proteins as Models to Study Structure/Biological Activities Relationships. Cavada BS, Pinto-Junior VR, Osterne VJS, Nascimento KS. Int J Mol Sci 20 (2018)
  2. Overview of the Structure⁻Function Relationships of Mannose-Specific Lectins from Plants, Algae and Fungi. Barre A, Bourne Y, Van Damme EJM, Rougé P. Int J Mol Sci 20 (2019)
  3. Research advances and prospects of legume lectins. Katoch R, Tripathi A. J Biosci 46 104 (2021)

Articles citing this publication (16)

  1. Vasodilator effects of Diocleinae lectins from the Canavalia genus. Assreuy AM, Fontenele SR, Pires Ade F, Fernandes DC, Rodrigues NV, Bezerra EH, Moura TR, do Nascimento KS, Cavada BS. Naunyn Schmiedebergs Arch. Pharmacol. 380 509-521 (2009)
  2. Effect of lectins from Diocleinae subtribe against oral Streptococci. Cavalcante TT, Anderson Matias da Rocha B, Alves Carneiro V, Vassiliepe Sousa Arruda F, Fernandes do Nascimento AS, Cardoso Sá N, do Nascimento KS, Sousa Cavada B, Holanda Teixeira E. Molecules 16 3530-3543 (2011)
  3. Structural analysis of ConBr reveals molecular correlation between the carbohydrate recognition domain and endothelial NO synthase activation. Bezerra EH, Rocha BA, Nagano CS, Bezerra Gde A, Moura TR, Bezerra MJ, Benevides RG, Sampaio AH, Assreuy AM, Delatorre P, Cavada BS. Biochem. Biophys. Res. Commun. 408 566-570 (2011)
  4. Structural studies of an anti-inflammatory lectin from Canavalia boliviana seeds in complex with dimannosides. Bezerra GA, Viertlmayr R, Moura TR, Delatorre P, Rocha BA, do Nascimento KS, Figueiredo JG, Bezerra IG, Teixeira CS, Simões RC, Nagano CS, de Alencar NM, Gruber K, Cavada BS. PLoS ONE 9 e97015 (2014)
  5. Protein crystal content analysis by mass spectrometry and preliminary X-ray diffraction of a lectin from Canavalia grandiflora seeds with modulatory role in inflammation. Simões RC, Rocha BA, Bezerra MJ, Barroso-Neto IL, Pereira-Junior FN, da Mata Moura R, do Nascimento KS, Nagano CS, Delatorre P, de Freitas Pires A, Assreuy AM, Sampaio AH, Cavada BS. Rapid Commun. Mass Spectrom. 26 811-818 (2012)
  6. Vasorelaxant activity of Canavalia grandiflora seed lectin: A structural analysis. Barroso-Neto IL, Simões RC, Rocha BA, Bezerra MJ, Pereira-Junior FN, Silva Osterne VJ, Nascimento KS, Nagano CS, Delatorre P, Pereira MG, Freitas Pires A, Sampaio AH, Assreuy AM, Cavada BS. Arch. Biochem. Biophys. 543 31-39 (2014)
  7. Structural characterization of a lectin from Canavalia virosa seeds with inflammatory and cytotoxic activities. Osterne VJS, Silva-Filho JC, Santiago MQ, Pinto-Junior VR, Almeida AC, Barreto AAGC, Wolin IAV, Nascimento APM, Amorim RMF, Rocha BAM, Delatorre P, Nagano CS, Leal RB, Assreuy AMS, Nascimento KS, Cavada BS. Int. J. Biol. Macromol. 94 271-282 (2017)
  8. The Arabidopsis AtLEC gene encoding a lectin-like protein is up-regulated by multiple stimuli including developmental signal, wounding, jasmonate, ethylene, and chitin elicitor. Lyou SH, Park HJ, Jung C, Sohn HB, Lee G, Kim CH, Kim M, Choi YD, Cheong JJ. Mol. Cells 27 75-81 (2009)
  9. Structural studies of a vasorelaxant lectin from Dioclea reflexa Hook seeds: Crystal structure, molecular docking and dynamics. Pinto-Junior VR, Osterne VJ, Santiago MQ, Correia JL, Pereira-Junior FN, Leal RB, Pereira MG, Chicas LS, Nagano CS, Rocha BA, Silva-Filho JC, Ferreira WP, Rocha CR, Nascimento KS, Assreuy AM, Cavada BS. Int. J. Biol. Macromol. 98 12-23 (2017)
  10. Crystal structure of the lectin of Camptosema pedicellatum: implications of a conservative substitution at the hydrophobic subsite. Souza Teixeira C, da Silva HC, de Moura TR, Pereira-Júnior FN, do Nascimento KS, Nagano CS, Sampaio AH, Delatorre P, Rocha BA, Cavada BS. J. Biochem. 152 87-98 (2012)
  11. Lectin from Canavalia brasiliensis seeds (ConBr) is a valuable biotechnological tool to stimulate the growth of Rhizobium tropici in vitro. de Vasconcelos MA, Cunha CO, Arruda FV, Carneiro VA, Mercante FM, do Nascimento Neto LG, de Sousa GS, Rocha BA, Teixeira EH, Cavada BS, dos Santos RP. Molecules 17 5244-5254 (2012)
  12. Canarosine: a new guanidine alkaloid from Canavalia rosea with inhibitory activity on dopamine D1 receptors. Pattamadilok D, Pengsuparp T, Phummiratch D, Ongpipattanakul B, Meksuriyen D, Kawanishi K, Kaneda N, Suttisri R. J Asian Nat Prod Res 10 915-918 (2008)
  13. Effects of Canavalia lectins on acute inflammation in sensitized and non-sensitized rats. Pinto NV, Cavada BS, Brito LF, Pereira RI, da Silva MT, Castro RR, de Freitas Pires A, Assreuy AM. Inflammation 36 713-722 (2013)
  14. Precipitation of sword bean proteins by heating and addition of magnesium chloride in a crude extract. Nishizawa K, Masuda T, Takenaka Y, Masui H, Tani F, Arii Y. Biosci. Biotechnol. Biochem. 80 1623-1631 (2016)
  15. Crystallization and preliminary X-ray diffraction analysis of the lectin from Canavalia boliviana Piper seeds. Moura TR, Bezerra GA, Bezerra MJ, Teixera CS, Bezerra EH, Benevides RG, da Rocha BA, de Souza LA, Delatorre P, Nagano CS, Cavada BS. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65 213-215 (2009)
  16. Exploration of the metal coordination region of concanavalin A for its interaction with human norovirus. Kim D, Lee HM, Oh KS, Ki AY, Protzman RA, Kim D, Choi JS, Kim MJ, Kim SH, Vaidya B, Lee SJ, Kwon J. Biomaterials 128 33-43 (2017)


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