2p34 › Citations

Structural analysis of Canavalia maritima and Canavalia gladiata lectins complexed with different dimannosides: new insights into the understanding of the structure-biological activity relationship in legume lectins.

Bezerra GA, Oliveira TM, Moreno FB, de Souza EP, da Rocha BA, Benevides RG, Delatorre P, de Azevedo WF, Cavada BS
J Struct Biol 160 168-76 (2007)
Related entries: 2ef6, 2ovu, 2ow4, 2p2k, 2p37

Cited: 27 times
EuropePMC logo PMID: 17881248

Abstract

Plant lectins, especially those purified from species of the Leguminosae family, represent the best studied group of carbohydrate-binding proteins. The legume lectins from Diocleinae subtribe are highly similar proteins that present significant differences in the potency/efficacy of their biological activities. The structural studies of the interactions between lectins and sugars may clarify the origin of the distinct biological activities observed in this high similar class of proteins. In this way, this work presents a crystallographic study of the ConM and CGL (agglutinins from Canavalia maritima and Canavalia gladiata, respectively) in the following complexes: ConM/CGL:Man(alpha1-2)Man(alpha1-O)Me, ConM/CGL:Man(alpha1-3)Man(alpha1-O)Me and ConM/CGL:Man(alpha1-4)Man(alpha1-O)Me, which crystallized in different conditions and space group from the native proteins. The structures were solved by molecular replacement, presenting satisfactory values for R(factor) and R(free). Comparisons between ConM, CGL and ConA (Canavalia ensiformis lectin) binding mode with the dimannosides in subject, presented different interactions patterns, which may account for a structural explanation of the distincts biological properties observed in the lectins of Diocleinae subtribe.

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  2. Extracellular Vesicles Secreted by Corneal Epithelial Cells Promote Myofibroblast Differentiation. McKay TB, Hutcheon AEK, Zieske JD, Ciolino JB. Cells 9 E1080 (2020)
  3. In silico identification of potential targets and drugs for non-small cell lung cancer. Huang CH, Wu MY, Chang PM, Huang CY, Ng KL. IET Syst Biol 8 56-66 (2014)
  4. A bead-based cleavage method for large-scale identification of protease substrates. Wang C, Ye M, Wei X, Bian Y, Cheng K, Zou H. Sci Rep 6 22645 (2016)
  5. A comparative study on normal and obese mice indicates that the secretome of mesenchymal stromal cells is influenced by tissue environment and physiopathological conditions. Ayaz-Guner S, Alessio N, Acar MB, Aprile D, Özcan S, Di Bernardo G, Peluso G, Galderisi U. Cell Commun Signal 18 118 (2020)
  6. Proteomic analysis reveals dysregulated cell signaling in ejaculated spermatozoa from infertile men. Samanta L, Sharma R, Cui Z, Agarwal A. Asian J Androl 21 121-130 (2019)
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Reviews citing this publication (3)

  1. ConA-Like Lectins: High Similarity Proteins as Models to Study Structure/Biological Activities Relationships. Cavada BS, Pinto-Junior VR, Osterne VJS, Nascimento KS. Int J Mol Sci 20 (2018)
  2. Overview of the Structure⁻Function Relationships of Mannose-Specific Lectins from Plants, Algae and Fungi. Barre A, Bourne Y, Van Damme EJM, Rougé P. Int J Mol Sci 20 (2019)
  3. Research advances and prospects of legume lectins. Katoch R, Tripathi A. J Biosci 46 104 (2021)

Articles citing this publication (16)



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