Function and Biology

Human aldose reductase mutant C303D complexed with fidarestat.

Source organism: Homo sapiens

EC 1.1.1.372: D/L-glyceraldehyde reductase

Reaction catalysed:
Glycerol + NADP(+) = D-glyceraldehyde + NADPH
Systematic name:
Glycerol:NADP(+) oxidoreductase (D/L-glyceraldehyde-forming)
Alternative Name(s):
  • GaaD (gene name)
  • Gld1 (gene name)

EC 1.1.1.54: Allyl-alcohol dehydrogenase

Reaction catalysed:
Allyl alcohol + NADP(+) = acrolein + NADPH
Systematic name:
Allyl-alcohol:NADP(+) oxidoreductase

EC 1.1.1.300: NADP-retinol dehydrogenase

Reaction catalysed:
All-trans-retinol + NADP(+) = all-trans-retinal + NADPH
Systematic name:
Retinol:NADP(+) oxidoreductase
Alternative Name(s):
  • All-trans retinal reductase
  • All-trans-retinol dehydrogenase
  • NADP(H)-dependent retinol dehydrogenase/reductase
  • PSDR1
  • RDH11
  • RDH12
  • RDH13
  • RDH14
  • RalR1
  • Retinol dehydrogenase (NADP(+))
  • Retinol dehydrogenase 12
  • Retinol dehydrogenase 14

EC 1.1.1.21: Aldose reductase

Reaction catalysed:
Alditol + NAD(P)(+) = aldose + NAD(P)H
Systematic name:
Alditol:NAD(P)(+) 1-oxidoreductase
Alternative Name(s):
  • ALR2
  • Aldehyde reductase
  • Alditol:NADP oxidoreductase
  • Alditol:NADP(+) 1-oxidoreductase
  • NADPH-aldopentose reductase
  • NADPH-aldose reductase
  • Polyol dehydrogenase (NADP(+))

Sequence family

Pfam Protein family (Pfam)
PF00248
Domain description: Aldo/keto reductase family
Occurring in:
  1. Aldo-keto reductase family 1 member B1
The deposited structure of PDB entry 2pdw contains 1 copy of Pfam domain PF00248 (Aldo/keto reductase family) in Aldo-keto reductase family 1 member B1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR020471
Domain description: Aldo-keto reductase
Occurring in:
  1. Aldo-keto reductase family 1 member B1
IPR018170
Domain description: Aldo/keto reductase, conserved site
Occurring in:
  1. Aldo-keto reductase family 1 member B1
IPR036812
Domain description: NADP-dependent oxidoreductase domain superfamily
Occurring in:
  1. Aldo-keto reductase family 1 member B1
IPR023210
Domain description: NADP-dependent oxidoreductase domain
Occurring in:
  1. Aldo-keto reductase family 1 member B1

Structure domain

CATH CATH domain
3.20.20.100
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: NADP-dependent oxidoreductase domain
Occurring in:
  1. Aldo-keto reductase family 1 member B1
The deposited structure of PDB entry 2pdw contains 1 copy of CATH domain 3.20.20.100 (TIM Barrel) in Aldo-keto reductase family 1 member B1. Showing 1 copy in chain A.