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Crystal structure of a putative muconate cycloisomerase from Sinorhizobium meliloti 1021

Source organism: Sinorhizobium meliloti 1021
Biochemical function: muconate cycloisomerase activity
Biological process: amino acid catabolic process
Cellular component: not assigned

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EC 5.5.1.1: Muconate cycloisomerase

Reaction catalysed:
(+)-muconolactone = cis,cis-muconate
Systematic name:
2,5-dihydro-5-oxofuran-2-acetate lyase (ring-opening)
Alternative Name(s):
  • 2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)
  • 4-carboxymethyl-4-hydroxyisocrotonolactone lyase (decyclizing)
  • CatB
  • Cis,cis-muconate cycloisomerase
  • Cis,cis-muconate lactonizing enzyme I
  • Cis,cis-muconate-lactonizing enzyme
  • MCl
  • Muconate cycloisomerase I
  • Muconate lactonizing enzyme

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF13378
Domain description: Enolase C-terminal domain-like
Occurring in:
  1. Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein
The deposited structure of PDB entry 2pgw contains 8 copies of Pfam domain PF13378 (Enolase C-terminal domain-like) in Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein. Showing 1 copy in chain C.

PF02746
Domain description: Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
Occurring in:
  1. Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein
The deposited structure of PDB entry 2pgw contains 8 copies of Pfam domain PF02746 (Mandelate racemase / muconate lactonizing enzyme, N-terminal domain) in Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR036849
Domain description: Enolase-like, C-terminal domain superfamily
Occurring in:
  1. Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein
IPR029017
Domain description: Enolase-like, N-terminal
Occurring in:
  1. Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein
IPR018110
Domain description: Mandelate racemase/muconate lactonizing enzyme, conserved site
Occurring in:
  1. Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein
IPR029065
Domain description: Enolase C-terminal domain-like
Occurring in:
  1. Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein
IPR013342
Domain description: Mandelate racemase/muconate lactonizing enzyme, C-terminal
Occurring in:
  1. Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein
IPR034593
Domain description: D-galactonate dehydratase DgoD-like
Occurring in:
  1. Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein
IPR013341
Domain description: Mandelate racemase/muconate lactonizing enzyme, N-terminal domain
Occurring in:
  1. Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein

Structure domains

CATH CATH domains
3.30.390.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Enolase-like; domain 1
Homology: Enolase-like, N-terminal domain
Occurring in:
  1. Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein
The deposited structure of PDB entry 2pgw contains 8 copies of CATH domain 3.30.390.10 (Enolase-like; domain 1) in Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein. Showing 1 copy in chain C.
3.20.20.120
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Enolase-like C-terminal domain
Occurring in:
  1. Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein
The deposited structure of PDB entry 2pgw contains 8 copies of CATH domain 3.20.20.120 (TIM Barrel) in Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein. Showing 1 copy in chain C.

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