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Model for VP16 binding to TFIIB

Source organisms:
Biochemical function: TBP-class protein binding
Biological process: transcription preinitiation complex assembly
Cellular component: not assigned

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EC 2.3.1.48: Histone acetyltransferase

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Systematic name:
Acetyl-CoA:[protein]-L-lysine acetyltransferase
Alternative Name(s):
  • Acetyl-CoA:histone acetyltransferase
  • Histone acetokinase
  • Histone acetylase
  • Histone transacetylase
  • Lysine acetyltransferase
  • Nucleosome-histone acetyltransferase
  • Protein lysine acetyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00382
Domain description: Transcription factor TFIIB repeat
Occurring in:
  1. Transcription initiation factor IIB
The deposited structure of PDB entry 2phg contains 2 copies of Pfam domain PF00382 (Transcription factor TFIIB repeat) in Transcription initiation factor IIB. Showing 2 copies in chain A.

PF12149
Domain description: Herpes simplex virus virion protein 16 C terminal
Occurring in:
  1. Tegument protein VP16
The deposited structure of PDB entry 2phg contains 1 copy of Pfam domain PF12149 (Herpes simplex virus virion protein 16 C terminal) in Tegument protein VP16. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000812
Domain description: Transcription factor TFIIB
Occurring in:
  1. Transcription initiation factor IIB
IPR023486
Domain description: Transcription factor TFIIB, conserved site
Occurring in:
  1. Transcription initiation factor IIB
IPR013763
Domain description: Cyclin-like domain
Occurring in:
  1. Transcription initiation factor IIB
IPR036915
Domain description: Cyclin-like superfamily
Occurring in:
  1. Transcription initiation factor IIB
IPR013150
Domain description: Transcription factor TFIIB, cyclin-like domain
Occurring in:
  1. Transcription initiation factor IIB
IPR021051
Domain description: Herpes simplex virus, Tegument protein VP16, C-terminal
Occurring in:
  1. Tegument protein VP16

Structure domain

CATH CATH domain
1.10.472.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Cyclin A; domain 1
Homology: Cyclin-like
Occurring in:
  1. Transcription initiation factor IIB
The deposited structure of PDB entry 2phg contains 2 copies of CATH domain 1.10.472.10 (Cyclin A; domain 1) in Transcription initiation factor IIB. Showing 2 copies in chain A.
SCOP SCOP annotation
47965
Class: All alpha proteins
Fold: Cyclin-like
Superfamily: Cyclin-like
Occurring in:
  1. Transcription initiation factor IIB
The deposited structure of PDB entry 2phg contains 2 copies of SCOP domain 47965 (Transcription factor IIB (TFIIB), core domain) in Transcription initiation factor IIB. Showing 2 copies in chain A.

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