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CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B (S)-2-(3-Aminomethyl-phenyl)-3-{hydroxy-[(R)-2-methyl-1-(3-phenyl-propane-1-sulfonylamino)-propyl]-phosphinoyl}-propionic acid {ZK 528} COMPLEX

Source organism: Sus scrofa
Biochemical function: zinc ion binding
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.17.2: Carboxypeptidase B

Reaction catalysed:
Preferential release of a C-terminal lysine or arginine amino acid.
Alternative Name(s):
  • Pancreatic carboxypeptidase B
  • Peptidyl-L-lysine (L-arginine)hydrolase
  • Protaminase
  • Tissue carboxypeptidase B

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00246
Domain description: Zinc carboxypeptidase
Occurring in:
  1. Carboxypeptidase B
The deposited structure of PDB entry 2piy contains 3 copies of Pfam domain PF00246 (Zinc carboxypeptidase) in Carboxypeptidase B. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000834
Domain description: Peptidase M14, carboxypeptidase A
Occurring in:
  1. Carboxypeptidase B
IPR034253
Domain description: Carboxypeptidase B, carboxypeptidase domain
Occurring in:
  1. Carboxypeptidase B

Structure domain

CATH CATH domain
3.40.630.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aminopeptidase
Homology: Zn peptidases
Occurring in:
  1. Carboxypeptidase B
The deposited structure of PDB entry 2piy contains 3 copies of CATH domain 3.40.630.10 (Aminopeptidase) in Carboxypeptidase B. Showing 1 copy in chain A.
SCOP SCOP annotation
53188
Class: Alpha and beta proteins (a/b)
Fold: Phosphorylase/hydrolase-like
Superfamily: Zn-dependent exopeptidases
Occurring in:
  1. Carboxypeptidase B
The deposited structure of PDB entry 2piy contains 3 copies of SCOP domain 53188 (Pancreatic carboxypeptidases) in Carboxypeptidase B. Showing 1 copy in chain A.

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