Function and Biology

Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I ) in Complex with KNI-10075

Source organism: Human immunodeficiency virus 1
Biochemical function: aspartic-type endopeptidase activity
Biological process: proteolysis
Cellular component: not assigned

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00077
Domain description: Retroviral aspartyl protease
Occurring in:
  1. Peptidase A2 domain-containing protein
The deposited structure of PDB entry 2pk5 contains 2 copies of Pfam domain PF00077 (Retroviral aspartyl protease) in Peptidase A2 domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR021109
Domain description: Aspartic peptidase domain superfamily
Occurring in:
  1. Peptidase A2 domain-containing protein
IPR001969
Domain description: Aspartic peptidase, active site
Occurring in:
  1. Peptidase A2 domain-containing protein
IPR001995
Domain description: Peptidase A2A, retrovirus, catalytic
Occurring in:
  1. Peptidase A2 domain-containing protein
IPR034170
Domain description: Retropepsin-like catalytic domain
Occurring in:
  1. Peptidase A2 domain-containing protein
IPR018061
Domain description: Retropepsins
Occurring in:
  1. Peptidase A2 domain-containing protein

Structure domain

CATH CATH domain
2.40.70.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Cathepsin D, subunit A; domain 1
Homology: Acid Proteases
Occurring in:
  1. Peptidase A2 domain-containing protein
The deposited structure of PDB entry 2pk5 contains 2 copies of CATH domain 2.40.70.10 (Cathepsin D, subunit A; domain 1) in Peptidase A2 domain-containing protein. Showing 1 copy in chain A.
SCOP SCOP annotation
50631
Class: All beta proteins
Fold: Acid proteases
Superfamily: Acid proteases
Occurring in:
  1. Peptidase A2 domain-containing protein
The deposited structure of PDB entry 2pk5 contains 2 copies of SCOP domain 50631 (Retroviral protease (retropepsin)) in Peptidase A2 domain-containing protein. Showing 1 copy in chain A.