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Crystal structure of recombinant full length human butyrylcholinesterase

Source organism: Homo sapiens
Biochemical function: carboxylic ester hydrolase activity
Biological process: response to folic acid
Cellular component: blood microparticle

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EC 3.1.1.8: Cholinesterase

Reaction catalysed:
An acylcholine + H(2)O = choline + a carboxylate
Systematic name:
Acylcholine acylhydrolase
Alternative Name(s):
  • Benzoylcholinesterase
  • BtChoEase
  • Butyrylcholine esterase
  • Butyrylcholinesterase
  • Choline esterase
  • Choline esterase II (unspecific)
  • Non-specific cholinesterase
  • Propionylcholinesterase
  • Pseudocholineesterase
  • Pseudocholinesterase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF08674
Domain description: Acetylcholinesterase tetramerisation domain
Occurring in:
  1. Cholinesterase
The deposited structure of PDB entry 2pm8 contains 2 copies of Pfam domain PF08674 (Acetylcholinesterase tetramerisation domain) in Cholinesterase. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

PF00135
Domain description: Carboxylesterase family
Occurring in:
  1. Cholinesterase
The deposited structure of PDB entry 2pm8 contains 2 copies of Pfam domain PF00135 (Carboxylesterase family) in Cholinesterase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000997
Domain description: Cholinesterase
Occurring in:
  1. Cholinesterase
IPR029058
Domain description: Alpha/Beta hydrolase fold
Occurring in:
  1. Cholinesterase
IPR014788
Domain description: Acetylcholinesterase, tetramerisation domain
Occurring in:
  1. Cholinesterase
IPR019826
Domain description: Carboxylesterase type B, active site
Occurring in:
  1. Cholinesterase
IPR019819
Domain description: Carboxylesterase type B, conserved site
Occurring in:
  1. Cholinesterase
IPR002018
Domain description: Carboxylesterase, type B
Occurring in:
  1. Cholinesterase

Structure domain

CATH CATH domain
3.40.50.1820
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: alpha/beta hydrolase
Occurring in:
  1. Cholinesterase
The deposited structure of PDB entry 2pm8 contains 2 copies of CATH domain 3.40.50.1820 (Rossmann fold) in Cholinesterase. Showing 1 copy in chain A.
SCOP SCOP annotation
53475
Class: Alpha and beta proteins (a/b)
Fold: alpha/beta-Hydrolases
Superfamily: alpha/beta-Hydrolases
Occurring in:
  1. Cholinesterase
The deposited structure of PDB entry 2pm8 contains 2 copies of SCOP domain 53475 (Acetylcholinesterase-like) in Cholinesterase. Showing 1 copy in chain A.

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