› 2ptk

X-ray diffraction
2.35Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132629 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chain: A
Molecule details ›
Chain: A
Length: 453 amino acids
Theoretical weight: 51.73 KDa
Source organism: Gallus gallus
Expression system: Not provided
UniProt:
  • Canonical: P00523 (Residues: 81-533; Coverage: 85%)
Gene name: SRC
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BL19
Spacegroup: P212121
Unit cell:
a: 52.561Å b: 89.252Å c: 97.392Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.204 0.292
Expression system: Not provided

Quick links

Citations

36 review citations

Free radicals in the physiological control of cell function.
Dröge W. (2002)
35 more

12 mentions without citation

Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases.
Haan et al. (2010)
11 more