› 2pw1

X-ray diffraction
2.6Å resolution

Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ELDKWNSL

Released:
DOI: 10.2210/pdb2pw1/pdb
PDB entry 2pw1 coloured by chain, front view.
PDB entry 2pw1 coloured by chain, side view.
PDB entry 2pw1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications.
Bryson S, Julien JP, Hynes RC, Pai EF
J Virol 83 11862-75 (2009)
PMID: 19740978

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-211603 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
2F5 Fab fragment heavy chain Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 23.36 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
2F5 Fab fragment light chain Chain: B
Molecule details ›
Chain: B
Length: 235 amino acids
Theoretical weight: 24.99 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
peptide epitope Chain: C
Molecule details ›
Chain: C
Length: 8 amino acids
Theoretical weight: 1.01 KDa

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P212121
Unit cell:
a: 58.1Å b: 65.2Å c: 175.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.213 0.24

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Citations

8 review citations

Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses.
Burton et al. (2012)
7 more

2 mentions without citation

Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications.
Bryson et al. (2009)
1 more