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Crystal structure of Imidazolonepropionase from environmental sample with bound inhibitor 3-(2,5-Dioxo-imidazolidin-4-yl)-propionic acid

Source organism: unidentified
Biochemical function: imidazolonepropionase activity
Biological process: L-histidine catabolic process to glutamate and formate
Cellular component: cytoplasm

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EC 3.5.2.7: Imidazolonepropionase

Reaction catalysed:
(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H(2)O = N-formimidoyl-L-glutamate + H(+)
Systematic name:
3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate amidohydrolase
Alternative Name(s):
  • 4(5)-imidazolone-5(4)-propionic acid hydrolase
  • Imidazolone propionic acid hydrolase
  • Imidazolone-5-propionate hydrolase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01979
Domain description: Amidohydrolase family
Occurring in:
  1. Imidazolonepropionase
The deposited structure of PDB entry 2q09 contains 1 copy of Pfam domain PF01979 (Amidohydrolase family) in Imidazolonepropionase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005920
Domain description: Imidazolonepropionase
Occurring in:
  1. Imidazolonepropionase
IPR011059
Domain description: Metal-dependent hydrolase, composite domain superfamily
Occurring in:
  1. Imidazolonepropionase
IPR032466
Domain description: Metal-dependent hydrolase
Occurring in:
  1. Imidazolonepropionase
IPR006680
Domain description: Amidohydrolase-related
Occurring in:
  1. Imidazolonepropionase

Structure domains

CATH CATH domains
2.30.40.10
Class: Mainly Beta
Architecture: Roll
Topology: Urease, subunit C; domain 1
Homology: Urease, subunit C, domain 1
Occurring in:
  1. Imidazolonepropionase
The deposited structure of PDB entry 2q09 contains 1 copy of CATH domain 2.30.40.10 (Urease, subunit C; domain 1) in Imidazolonepropionase. Showing 1 copy in chain A.
3.20.20.140
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Metal-dependent hydrolases
Occurring in:
  1. Imidazolonepropionase
The deposited structure of PDB entry 2q09 contains 1 copy of CATH domain 3.20.20.140 (TIM Barrel) in Imidazolonepropionase. Showing 1 copy in chain A.
SCOP SCOP annotations
159347
Class: All beta proteins
Fold: Composite domain of metallo-dependent hydrolases
Superfamily: Composite domain of metallo-dependent hydrolases
Occurring in:
  1. Imidazolonepropionase
The deposited structure of PDB entry 2q09 contains 1 copy of SCOP domain 159347 (Imidazolonepropionase-like) in Imidazolonepropionase. Showing 1 copy in chain A.
159400
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Metallo-dependent hydrolases
Occurring in:
  1. Imidazolonepropionase
The deposited structure of PDB entry 2q09 contains 1 copy of SCOP domain 159400 (Imidazolonepropionase-like) in Imidazolonepropionase. Showing 1 copy in chain A.

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