› 2q36

X-ray diffraction
2.5Å resolution

Actin Dimer Cross-linked between Residues 191 and 374 and complexed with Kabiramide C

Released:
DOI: 10.2210/pdb2q36/pdb
PDB entry 2q36 coloured by chain, front view.
PDB entry 2q36 coloured by chain, side view.
PDB entry 2q36 coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Multiple crystal structures of actin dimers and their implications for interactions in the actin filament.
Sawaya MR, Kudryashov DS, Pashkov I, Adisetiyo H, Reisler E, Yeates TO
OpenAccess logo Acta Crystallogr D Biol Crystallogr 64 454-65 (2008)
PMID: 18391412

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159317 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actin, alpha skeletal muscle Chain: A
Molecule details ›
Chain: A
Length: 375 amino acids
Theoretical weight: 41.86 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P68135 (Residues: 3-377; Coverage: 100%)
Gene names: ACTA, ACTA1
Sequence domains: Actin
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand CA 1 x CA
Ligand SO4 2 x SO4
Ligand ATP 1 x ATP
Ligand KAB 1 x KAB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P212121
Unit cell:
a: 40.539Å b: 74.276Å c: 144.474Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.175 0.223

Quick links

Citations

3 review citations

Actin structure and function.
Dominguez et al. (2011)
2 more

98 mentions without citation

Clinical, genetic and imaging findings identify new causes for corpus callosum development syndromes.
Edwards et al. (2014)
97 more