› 2q85

X-ray diffraction
2.51Å resolution

Crystal Structure of E. Coli Mur B bound to a Naphthyl Tetronic Acid inihibitor

Released:
DOI: 10.2210/pdb2q85/pdb
PDB entry 2q85 coloured by chain, front view.
PDB entry 2q85 coloured by chain, side view.
PDB entry 2q85 coloured by chain, top view.
Source organism: Escherichia coli
Entry authors: Chopra R, Bard J, Svenson K, Mansour T

Function and Biology Details

Reaction catalysed: 
UDP-N-acetyl-alpha-D-muramate + NADP(+) = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-530618 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UDP-N-acetylenolpyruvoylglucosamine reductase Chain: A
Molecule details ›
Chain: A
Length: 342 amino acids
Theoretical weight: 37.89 KDa
Source organism: Escherichia coli
UniProt:
  • Canonical: P08373 (Residues: 1-342; Coverage: 100%)
Gene names: JW3940, b3972, murB, yijB
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 1 x FAD
1 bound ligand:
Ligand 973 1 x 973
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P21
Unit cell:
a: 41.993Å b: 89.301Å c: 50.943Å
α: 90° β: 111.11° γ: 90°
R-values:
R R work R free
0.24 0.166 0.244

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