Function and Biology

crystal structure of mouse GITR ligand dimer

Source organism: Mus musculus
Biochemical function: tumor necrosis factor receptor superfamily binding
Biological process: tumor necrosis factor-mediated signaling pathway
Cellular component: not assigned

Sequence family

Pfam Protein family (Pfam)
PF00229
Domain description: TNF(Tumour Necrosis Factor) family
Occurring in:
  1. Tumor necrosis factor ligand superfamily member 18

InterPro InterPro annotations
IPR008983
Domain description: Tumour necrosis factor-like domain superfamily
Occurring in:
  1. Tumor necrosis factor ligand superfamily member 18
IPR042380
Domain description: Tumor necrosis factor ligand superfamily member 18
Occurring in:
  1. Tumor necrosis factor ligand superfamily member 18

Structure domain

CATH CATH domain
2.60.120.40
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. Tumor necrosis factor ligand superfamily member 18
The deposited structure of PDB entry 2q8o contains 2 copies of CATH domain 2.60.120.40 (Jelly Rolls) in Tumor necrosis factor ligand superfamily member 18. Showing 1 copy in chain A.
SCOP SCOP annotation
49843
Class: All beta proteins
Fold: TNF-like
Superfamily: TNF-like
Occurring in:
  1. Tumor necrosis factor ligand superfamily member 18
The deposited structure of PDB entry 2q8o contains 2 copies of SCOP domain 49843 (TNF-like) in Tumor necrosis factor ligand superfamily member 18. Showing 1 copy in chain A.