› 2qms

X-ray diffraction
2.1Å resolution

Crystal structure of a signaling molecule

Released:
DOI: 10.2210/pdb2qms/pdb
PDB entry 2qms coloured by chain, front view.
PDB entry 2qms coloured by chain, side view.
PDB entry 2qms coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation.
Porter CJ, Matthews JM, Mackay JP, Pursglove SE, Schmidberger JW, Leedman PJ, Pero SC, Krag DN, Wilce MC, Wilce JA
OpenAccess logo BMC Struct Biol 7 58 (2007)
PMID: 17894853

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172006 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth factor receptor-bound protein 7 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 120 amino acids
Theoretical weight: 13.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14451 (Residues: 415-532; Coverage: 22%)
Gene name: GRB7
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

1 bound ligand:
Ligand SO4 7 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P212121
Unit cell:
a: 62.649Å b: 63.904Å c: 105.685Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.201 0.255
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Progress towards the development of SH2 domain inhibitors.
Kraskouskaya et al. (2013)
3 more

8 mentions without citation

Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation.
Porter et al. (2007)
7 more