› 2qr8

X-ray diffraction
2Å resolution

2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2 (RSK2)

Released:
DOI: 10.2210/pdb2qr8/pdb
PDB entry 2qr8 coloured by chain, front view.
PDB entry 2qr8 coloured by chain, side view.
PDB entry 2qr8 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2.
Malakhova M, Tereshko V, Lee SY, Yao K, Cho YY, Bode A, Dong Z
Nat Struct Mol Biol 15 112-3 (2008)
PMID: 18084304

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-538977 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosomal protein S6 kinase alpha-3 Chain: A
Molecule details ›
Chain: A
Length: 342 amino acids
Theoretical weight: 38.48 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P18654 (Residues: 399-740; Coverage: 46%)
Gene names: Mapkapk1b, Rps6ka-rs1, Rps6ka3, Rsk2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P41212
Unit cell:
a: 46.912Å b: 46.912Å c: 291.076Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.215 0.259
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores.
Gógl et al. (2019)
2 more

9 mentions without citation

Therapeutic targeting of p90 ribosomal S6 kinase.
Wright et al. (2023)
8 more