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Crystal Structure of Arabidopsis thaliana 5'-Methylthioadenosine nucleosidase in complex with 5'-methylthiotubercidin

Source organism: Arabidopsis thaliana
Biochemical function: hydrolase activity
Biological process: L-methionine salvage from methylthioadenosine
Cellular component: plasma membrane

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EC 3.2.2.16: Methylthioadenosine nucleosidase

Reaction catalysed:
S-methyl-5'-thioadenosine + H(2)O = 5-(methylsulfanyl)-D-ribose + adenine
Systematic name:
S-methyl-5'-thioadenosine adeninehyrolase
Alternative Name(s):
  • 5'-methylthioadenosine nucleosidase
  • MTA nucleosidase
  • MeSAdo nucleosidase
  • Methylthioadenosine methylthioribohydrolase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01048
Domain description: Phosphorylase superfamily
Occurring in:
  1. 5'-methylthioadenosine nucleosidase
The deposited structure of PDB entry 2qtg contains 2 copies of Pfam domain PF01048 (Phosphorylase superfamily) in 5'-methylthioadenosine nucleosidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR035994
Domain description: Nucleoside phosphorylase superfamily
Occurring in:
  1. 5'-methylthioadenosine nucleosidase
IPR000845
Domain description: Nucleoside phosphorylase domain
Occurring in:
  1. 5'-methylthioadenosine nucleosidase
IPR044580
Domain description: 5'-Methylthioadenosine/S-adenosylhomocysteine nucleosidase
Occurring in:
  1. 5'-methylthioadenosine nucleosidase

Structure domain

CATH CATH domain
3.40.50.1580
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Nucleoside phosphorylase domain
Occurring in:
  1. 5'-methylthioadenosine nucleosidase
The deposited structure of PDB entry 2qtg contains 2 copies of CATH domain 3.40.50.1580 (Rossmann fold) in 5'-methylthioadenosine nucleosidase. Showing 1 copy in chain A.

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