› 2qyp

X-ray diffraction
2.45Å resolution

Orthorhombic Crystal Structure of Human Saposin C Dimer in Open Conformation

Released:
DOI: 10.2210/pdb2qyp/pdb
Model geometry
Fit model/data
PDB entry 2qyp coloured by chain, front view.
PDB entry 2qyp coloured by chain, side view.
PDB entry 2qyp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human saposins C andD: implications for lipid recognition and membrane interactions.
Rossmann M, Schultz-Heienbrok R, Behlke J, Remmel N, Alings C, Sandhoff K, Saenger W, Maier T
Structure 16 809-17 (2008)
PMID: 18462685

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139657 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Saposin-C Chains: A, B
Molecule details ›
Chains: A, B
Length: 91 amino acids
Theoretical weight: 10.38 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P07602 (Residues: 311-392; Coverage: 16%)
Gene names: GLBA, PSAP, SAP1
Sequence domains:
Structure domains: Saposin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ENRAF-NONIUS FR571
Spacegroup: C2221
Unit cell:
a: 57.008Å b: 88.904Å c: 93.465Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.229 0.29
Expression system: Komagataella pastoris

Quick links

Citations

15 review citations

Lysosomal degradation of membrane lipids.
Kolter et al. (2010)
14 more

12 mentions without citation

Mechanism of glucocerebrosidase activation and dysfunction in Gaucher disease unraveled by molecular dynamics and deep learning.
Romero et al. (2019)
11 more