EC 1.1.1.34: Hydroxymethylglutaryl-CoA reductase (NADPH)
Reaction catalysed:
(R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH
Systematic name:
(R)-mevalonate:NADP(+) oxidoreductase (CoA-acylating)
Alternative Name(s):
- 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
- 3-hydroxy-3-methylglutaryl-CoA reductase
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- Beta-hydroxy-beta-methylglutaryl coenzyme A reductase
- HMG-CoA reductase
- HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA)
- Hydroxymethylglutaryl CoA reductase (NADPH)
- Hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate)
- Hydroxymethylglutaryl-CoA reductase (NADPH(2))
- NADPH-hydroxymethylglutaryl-CoA reductase
- S-3-hydroxy-3-methylglutaryl-CoA reductase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence family
Protein family (Pfam)
InterPro annotations
IPR023076
Domain description:
Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
Occurring in:
Occurring in:
IPR004554
Domain description:
Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type
Occurring in:
Occurring in:
IPR009023
Domain description:
Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily
Occurring in:
Occurring in:
IPR023074
Domain description:
Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily
Occurring in:
Occurring in:
IPR009029
Domain description:
Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily
Occurring in:
Occurring in:
Structure domains
CATH domains
3.90.770.10
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Homology:
3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Occurring in:
3.30.70.420
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Alpha-Beta Plaits
Homology:
Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
Occurring in: